In the season premiere episode, “Stranger in a Strange Land,” Sam (Jared Padalecki) enlists everyone's help in trying to track down Dean (Jensen Ackles), who can literally be anywhere. Meanwhile, Castiel (Misha Collins) may be in over his head after meeting up with an unreliable source. After being drained of his grace in season 13, Jack (Alexander Calvert) is adjusting to life as a human, learning new skills and figuring out how he fits in to this world of hunters.
Supernatural revolves around the thrilling and terrifying journey of the Winchester brothers who have spent their lives on the road, battling every kind of supernatural threat. Over the years, after countless bloody adventures, they have faced everything from the yellow-eyed demon that killed their mother to vampires, ghosts, shapeshifters, angels and fallen gods. With the help of allies, both human and supernatural, they’ve discovered that every victory comes with a price.