Following the startling revelation that Raymond "Red" Reddington (James Spader) isn't who he says he is, Elizabeth Keen (Megan Boone) is torn between the relationship she's developed with the man assumed to be her father and her desire to get to the bottom of years of secrets and lies.
Meanwhile, Red leads Liz and the FBI to some of the most strange and dangerous criminals yet, growing his empire and eliminating rivals in the process. All throughout, Liz and Red engage in an uneasy cat-and-mouse game in which lines will be crossed and the truth will be revealed.
In the season premiere, Dr. Hans Koehler, Red (James Spader) presents the Task Force with a Blacklist case searching for a plastic surgeon who creates new identities for wanted criminals. Meanwhile, Liz (Megan Boone) and her sister Jennifer (guest star Fiona Dourif) secretly investigate the events that took place the night the real Raymond Reddington died. Diego Klattenhoff, Amir Arison, Mozhan Marnò, Hisham Tawfiq and Harry Lennix also star. Kenneth Tigar and Christopher Lambert also guest star.